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The Advanced Microscopy Facility hosts instruments across self-driving labs, confocal, single-molecule super-resolution, STED, scanning probe, near-field, and correlative imaging. Each entry below opens to specifications, location, and access details.

01
AFM · Asylum / Oxford

AFM Cypher ES

Atomic force microscope, sub-nm topology in dry and liquid environments.

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02
Confocal · Nikon

Nikon AX with NSPARC

Confocal with the NSPARC super-resolution detector, around 120 nm lateral, in AdBio Lab, Helix.

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03
Confocal · Nikon

Nikon A1R HD25

Confocal with 25 mm field of view, 8 kHz resonant scanner, six lasers, temperature-controlled stages. Hosted by Janne-Mieke Meijer’s group, Flux.

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04
Confocal · Nikon

Nikon A1

Older Nikon confocal at AMF, sharing the Ti2 body with the Abbelight SAFe-360 in Flux 4.102.

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05
Correlative · Zeiss / Thermo Fisher

CLEM (Zeiss + Glacios)

Cryo-fluorescence on a Zeiss AxioImager with Linkam cryo-stage, correlative with Thermo Fisher Glacios cryoTEM at CMEM.

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06
Custom · ICMS-AMF

Custom-built microscopy

Bespoke optical setups for imaging questions off-the-shelf systems cannot answer.

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07
Custom · MBx · Single Particle Metrology

iSCAT

Home-built interferometric scattering microscope for label-free imaging of single proteins, vesicles, viruses, and nanoparticles. Mass photometry and iNTA, with fluorescence channels coming.

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08
Custom · TU/e Applied Physics · Tielrooij group

Spatiotemporal Microscopy

Ultrafast pump–probe microscopy for direct imaging of heat, charge, and exciton diffusion in thin films, 2D materials, and nanoribbons. Femtosecond temporal, sub-micron spatial.

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09
Near-field · Neaspec

Cryo-neaSNOM

Scanning near-field optical microscope, vis/IR/THz, cryogenic temperatures. Hosted by Klaas-Jan Tielrooij’s group.

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SDL
SDL · BigChemistry · TU/e

Robotlab SDL

Closed-loop SDL on a Confocal.nl NL5+ confocal driven by Micro-Manager (open-source, Fiji/ImageJ-based). Coacervates, condensates, soft materials. Hosted by Yannick Leurs and Willem van den Hout.

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SDL
SDL · BigChemistry · TU/e

PhaseXplorer SDL

Autonomous mapping of phase-separation across multivariate spaces — 100× faster, 10,000× less material. Confocal.nl NL5+ on Micro-Manager. Hosted by Nadia Erkamp in Ceres.

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SDL
SDL · BigChemistry · TU/e

Xperimate SDL

Autonomous formulation, application, and analysis of coatings, inks, and paints — wet and dry. AI/ML guided. Hosted by Joost van der Tol and Ghislaine Vantomme.

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10
SMLM · Nikon

Nikon N-STORM

TIRF-based SMLM on a Nikon Ti-E body, 405 to 637 nm excitation, photoactivation.

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11
SMLM · ONI

Oxford Nanoimager (ONI)

Desktop SMLM workhorse, dSTORM and single-particle tracking in live cells.

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12
SMLM · Abbelight

Abbelight SAFe-360

Multi-colour SMLM with DNA-PAINT, on a Nikon Ti2 body, in Flux 4.102.

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13
STED · Abberior

Abberior STED ExpertLine

STED super-resolution microscope, real-time scanning, live-cell capable.

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